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目的 分析经导管眼动脉灌注化疗术治疗眼内晚期化疗失败的视网膜母细胞瘤的临床疗效及安全性.方法随机选取我院2010G7-2015G12收治的眼内晚期化疗失败的视网膜母细胞瘤患儿16例(23只眼),依据治疗方法将这些患儿均经眼部B超、Retcam眼底照相检查等确诊为视网膜母细胞瘤,分为经导管眼动脉灌注化疗术组(研究组,n=8,11只眼)和眼球摘除术组(对照组,n=8,12只眼)两组,对两组患儿的临床疗效、并发症发生情况及复发情况进行统计分析.结果 研究组患儿治疗的总有效率727%(8/11)显著高于对照组417%(5/12)(P<005),眼结膜充血、玻璃体出血、眼球外斜、脱发、肝肾功能损害、听力损害、导管相关并发症发生率及复发率均显著低于对照组(P<005),两组患儿的眼睑肿胀、多泪、胃肠道反应、一过性骨髓抑制发生率之间的差异均不显著(P>005).结论 经导管眼动脉灌注化疗术治疗眼内晚期化疗失败的视网膜母细胞瘤的临床疗效较眼球摘除术显著,且具有较高的安全性.
Objective To analyze the clinical efficacy and safety of transcatheter arterial infusion chemotherapy in the treatment of retinoblastoma failed in late intraocular chemotherapy.Methods Children with retinoblastoma who had failed intraocular chemotherapy at 2010G7-2015G12 were selected randomly (23 eyes). According to the treatment method, these children were diagnosed as retinoblastoma by eye B ultrasound and Retcam fundus examination respectively. The patients were divided into transcatheter arterial infusion chemotherapy group (n = 8 , 11 eyes) and enucleated group (control group, n = 8, 12 eyes), the clinical efficacy, complications and recurrence of the two groups were statistically analyzed.Results In the study group, children The total effective rate of treatment was 727% (8/11), which was significantly higher than that of the control group (417%, 5/12) (P <005), conjunctival hyperemia, vitreous hemorrhage, extraocular obliquity, hair loss, liver and kidney dysfunction, hearing loss , The incidence of catheter-related complications and recurrence rate were significantly lower than the control group (P <005), two groups of children with eyelid swelling, multiple tears, gastrointestinal reactions, the incidence of transient bone marrow suppression differences were (P> 005) .Conclusion Transcatheter arterial infusion chemotherapy for the treatment of late intraocular The clinical efficacy of chemotherapy-failed retinoblastoma is more significant than enucleation and has higher safety.