【摘 要】
：
目的 探讨不同水溶性有机磷杀虫剂(OP)其游离毒剂(FOP)在染毒家兔血及脂肪组织中的分布过程和意义.方法 72只雄性青紫兰家兔分为3组:久效磷5 LD50组(11.12mg/kg),敌百虫5 LD5
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目的 探讨不同水溶性有机磷杀虫剂(OP)其游离毒剂(FOP)在染毒家兔血及脂肪组织中的分布过程和意义.方法 72只雄性青紫兰家兔分为3组:久效磷5 LD50组(11.12mg/kg),敌百虫5 LD50组(556.0mg/kg),甲基对硫磷5LD50组(37.05mg/kg).每组24只,每小组6只.家兔染毒经皮下给药.染毒后1,6,24,96 h取血和脂肪组织,分离血细胞和血浆,制备脂肪组织匀浆,用DTNB酶动力学法测乙酰胆碱酯酶(AChE)活力,酶抑制法测游离有机磷毒质(FOP)含量.结果 染毒后1,6,24h,久效磷、敌百虫、甲基对硫磷染毒血浆间比较,血细胞间比较和脂肪组织间比较,FOP浓度差异具有统计学意义(血浆:P＜0.05；血细胞:P＜0.05；脂肪:P＜0.05)；相同时相久效磷脂肪组织FOP浓度与血浆和血细胞比较差异无统计学意义(P＞0.05),敌百虫脂肪组织FOP含量为血浆和血细胞的数倍(P＜0.05),而甲基对硫磷FOP浓度在1、6h与血细胞接近(P＞0.05)但低于血浆(P＜0.05),染毒后24h脂肪组织、血细胞、血浆FOP浓度接近平衡(P＞0.05).三种OP血浆、脂肪组织清除率不同,久效磷＞敌百虫＞甲基对硫磷.结论 有机磷杀虫剂随水溶性的降低,对脂肪组织的亲和性增强,FOP由血和脂肪组织被清除的时间相应延长.脂肪组织是水溶性差的有机磷杀虫剂的储存库.
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