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观察了双侧髂股动脉去内皮及高胆固醇饲料喂养诱发的动脉粥样硬化兔细胞膜 Ca~(2+)-ATP 酶活性的变化及药物穿心莲和鱼油对粥样硬化的预防作用及对 Ca~(2+)-ATP酶活性的影响。结果表明,Ca~(2+)-ATP 酶活性:粥样硬化组显著低于正常组(P<0.01)及两个药物处理组(P<0.05);血管造影见粥样硬化组双髂动脉均形成明显狭窄或闭塞,穿心莲提取物和鱼油均能明显降低狭窄发生率,减轻狭窄程度,尤以前者更明显。作者认为:由于某些因素使细胞膜 Ca~(2+)-ATP 酶活性下降,导致细胞内 Ca~(2+)浓度增加,从而促进血小板和单核细胞等分泌生长因子并促进血管平滑肌细胞向内膜移行和过度增生,形成粥样硬化病变。穿心莲提取物和鱼油能防止细胞膜 Ca~(2+)-ATP 酶活性下降,因而能显著减轻粥样硬化病变。
The changes of Ca ~ (2 +) - ATPase activity in atherosclerotic rabbits and the prevention of atherosclerosis in atherosclerotic rabbits induced by feeding of both the iliac femoral artery and the diet of high cholesterol were observed. (2 +) - ATPase activity. The results showed that the activity of Ca ~ (2 +) - ATPase in atherosclerosis group was significantly lower than that in normal group (P <0.01) and two drug treatment groups (P <0.05) Were significantly stenosed or occluded, andrographolide extract and fish oil can significantly reduce the incidence of stenosis, reduce the degree of stenosis, especially the former is more obvious. The authors suggest that due to some factors, the Ca (2 +) - ATPase activity of the cell membrane is decreased, leading to the increase of intracellular Ca2 + concentration, thereby promoting the secretion of growth factors such as platelet and monocyte and promoting the proliferation of vascular smooth muscle cells Endometrial migration and hyperplasia, the formation of atherosclerotic lesions. Andrographis paniculata extract and fish oil can prevent cell membrane Ca2 + - ATPase activity decreased, thus significantly reduce atherosclerotic lesions.