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亨氏舞蹈症(HD)基因被定位在4p16.3上,作者应用连锁不平衡的单倍型集中分析4p16.3上可能是缺陷部位的一个小片段。应用外显子捕获技术从靶区分离到一个位于HD染色体上的新基因IT_(15),它包含一个多态的、加长的和不稳定的三核苷酸重
Heinz Chorea (HD) gene is mapped on 4p16.3 and the authors used a linkage disequilibrium haplotype to focus on a small segment of the 4p16.3 that may be a defective site. A novel gene IT_ (15) located on the HD chromosome was isolated from the target using exon capture technology and contained a polymorphic, lengthened and unstable trinucleotide