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目的观察术前抗内毒素治疗对阻塞性黄疸病人内毒素血症的抑制作用。方法阻塞性黄疸病人分三组在术前分别给予一般治疗(OJ组),口服胆盐(OJT_1 组)和静脉注射抗内毒素抗体(()JT_2组).观察血浆内毒索(ET)、及肿瘤坏死因子(TNF)含量变化。结果三组术前ET和TNF水平无差异。()JT_1和()T_2组用药后血浆ET水平均显著下降,明显低于()J组(P<0.01),术后进一步降低()JT和()T_ 2组术前和术后ET水平与()J组无明显差异。结论术前应用胆盐和抗体可有效降低梗黄病入围手术期血浆ET水平。
Objective To observe the inhibitory effect of preoperative anti-endotoxin treatment on endotoxemia in patients with obstructive jaundice. Methods Patients with obstructive jaundice were divided into three groups: OJ group, oral bile salt (OJT1) group and intravenous anti-endotoxin antibody group (JT2). The levels of plasma endotoxin (ET) And tumor necrosis factor (TNF) content changes. Results There was no difference in the levels of ET and TNF between the three groups before operation. (P <0.01), the levels of ET in JT_1 and (T_2) groups decreased significantly (P <0.01), and the levels of ET in JT_1 group and (T_2) group decreased And () J group no significant difference. Conclusions The application of bile salt and antibody before operation can effectively reduce the level of plasma ET during the perioperative period.