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以蔗渣木聚糖(BX)为主要原料、没食子酸为酯化剂、三乙胺为催化剂、N,N-二甲基甲酰胺(DMF)为溶剂,合成了蔗渣木聚糖没食子酸酯(Ⅰ),接着以过硫酸铵引发甲基丙烯酸(MAA)和丙烯酸丁酯(BA)与Ⅰ共聚,合成了蔗渣木聚糖没食子酸酯-g-MAA/BA酯化接枝共聚物(Ⅱ)。考察了合成工艺参数对其取代度(DS)、接枝率(G)和接枝效率(GE)的影响。采用FTIR、SEM、XRD与TG-DTG对产物的结构和性能进行了表征。结果表明:在n(BX)∶n(三乙酰没食子酰氯)=1∶1、m(DMF)∶m(BX)=9.5∶1.0、45℃下反应4.0 h时,产物Ⅰ的DS为0.64;在n(Ⅰ)∶n(BA)∶n(MAA)=1∶1∶1、w(过硫酸铵)=7%、50℃下反应8.0 h时,接枝共聚物Ⅱ的G和GE分别为23%和67%。采用溴化噻唑蓝四氮唑(MTT)法对Ⅱ进行了抗癌活性测试。结果表明:当Ⅱ的质量浓度为100 mg/L时,其对肝癌细胞的抑制率达28.83%。
Using bagasse xylan (BX) as main raw material, gallic acid as esterification agent, triethylamine as catalyst and N, N-dimethylformamide as solvent, bagasse xylose gallate (Ⅱ) was synthesized by copolymerization of ammonium methacrylate (MAA) and butyl acrylate (BA) with Ⅰ by ammonium persulfate. . The effects of synthesis parameters on the degree of substitution (DS), grafting rate (G) and grafting efficiency (GE) were investigated. The structure and properties of the product were characterized by FTIR, SEM, XRD and TG-DTG. The results showed that the DS of product Ⅰ was 0.64 when the reaction was carried out at n (BX) = n (triacetyl galloyl chloride) = 1: 1, m (DMF): m (BX) = 9.5:1.0 at 45 ℃ for 4.0 h. G and GE of the graft copolymer II were respectively measured at n (Ⅰ): n (BA): n (MAA) = 1: 1:1, w (ammonium persulfate) = 7% and reaction at 50 ℃ for 8.0 h 23% and 67%. The anti-cancer activity of Ⅱ was tested by MTT method. The results showed that when the concentration of Ⅱ was 100 mg / L, the inhibitory rate of HCC cells was 28.83%.