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目的研究肥胖和超重学生糖、脂代谢有关的生化指标特点及肥胖项目干预后的变化,为探索有效的肥胖干预效果评价指标提供依据。方法在上海市健康示范学院抽取1所小学和1所初级中学,筛查出55名肥胖学生,在超重、正常学生中按肥胖学生的年龄、性别进行配对;然后在未开展健康示范的学校中按干预学校学生的年龄、性别分别确定肥胖、超重学生各55名。各组对象均用相同年龄、性别的1∶1配对t检验分析。检测生化指标包括谷丙转氨酶(ALT)、胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FG)、空腹胰岛素(F ins)、HOMA胰岛素抵抗指数(HOMA-IR)。结果干预前,肥胖、超重学生的ALT、TG、空腹胰岛素、HOMA-IR均明显高于正常学生。ALT在肥胖、超重、正常学生分别为32,24,15 U/L,TG分别为1.03,0.92,0.80mmol/L,空腹胰岛素分别为14.70,12.34,5.97 IU,HOMA-IR分别为2.97,2.49,1.20。干预后,干预学校肥胖、超重学生的ALT、TG、空腹胰岛素、HOMA-IR均明显下降,肥胖组分别为20 U/L,0.90 mmol/L,11.93 IU,2.42,超重组分别为13 U/L,0.85 mmol/L,10.30 IU,2.05。同期对照学校干预后与干预前,肥胖学生ALT、空腹胰岛素、HOMA-IR明显上升,分别为32 U/L和26 U/L,20.76 IU和12.77 IU,4.57和2.56。结论肥胖、超重学生中存在明显的糖、脂代谢紊乱。健康示范学校创建项目能有效改善糖、脂代谢紊乱。在减肥评估中,除体重指标外,可增加一些生化指标,如ALT、HOMA-IR。
Objective To study the characteristics of biochemical indexes related to sugar and lipid metabolism in obese and overweight students and the changes after obesity intervention in obese and overweight students, so as to provide basis for exploring the effective evaluation index of obesity intervention. Methods A total of 55 obese students were screened from 1 primary school and 1 junior high school in Shanghai Health Demonstration College. The obese students were matched according to the age and sex of overweight and normal students. Then, in the schools without health demonstration According to the age and sex of the intervention school students, 55 obese and overweight students were respectively identified. Each group of patients with the same age, sex, 1: 1 paired t test analysis. The biochemical parameters of ALT, TC, TG, HDL-C, LDL-C and fasting blood glucose (FG) , Fasting insulin (F ins), HOMA insulin resistance index (HOMA-IR). Results Before intervention, obese, overweight students ALT, TG, fasting insulin, HOMA-IR were significantly higher than normal students. ALT was obese, overweight and normal students were 32,24,15 U / L, TG were 1.03,0.92,0.80mmol / L, fasting insulin were 14.70,12.34,5.97 IU, HOMA-IR were 2.97,2.49 , 1.20. After intervention, the levels of ALT, TG, fasting insulin and HOMA-IR of obese and overweight students in intervention group were significantly lower than those in obese group (20 U / L, 0.90 mmol / L, 11.93 IU, 2.42, L, 0.85 mmol / L, 10.30 IU, 2.05. In the same period, ALT, fasting insulin and HOMA-IR of obese students increased significantly after school intervention and before intervention, respectively, 32 U / L and 26 U / L, 20.76 IU and 12.77 IU, 4.57 and 2.56 respectively. Conclusion Obesity and overweight students have obvious disorders of glucose and lipid metabolism. Health demonstration school to create a project can effectively improve the sugar and lipid metabolism disorders. In weight loss assessment, in addition to body mass index, you can add some biochemical indicators, such as ALT, HOMA-IR.