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近来,由于糖尿病((?))患者寿命的延长,使血管损害的发生率有升高趋势。胶原中存在着其它蛋白质中没有的两种天然的标志-羟脯氨酸和羟赖氨酸。因而可通过对尿及血清中这种蛋白质代谢的分析来研究胶原代谢。作者研究了214例17～40岁无并发症的糖尿病患者(男111,女103)的羟脯氨酸代谢,其中,轻型糖尿病16例,中型103例,重型95例。在临床出现不同部位糖尿病性微血管病患者中,有70例为中型,72例为重型。测定了24小时尿羟脯氨酸排泄量、血清游离羟脯氨酸含量及与血清胶原样蛋白结合的
Recently, due to diabetes ((?)) Patients with life expectancy, the incidence of vascular damage have increased. Collagen contains two other natural markers that are not found in other proteins, hydroxyproline and hydroxylysine. Thus collagen metabolism can be studied by analyzing this protein metabolism in urine and serum. The authors studied hydroxyproline metabolism in 214 patients 17 to 40 years of age without complications (male 111, female 103), of whom 16 were light-to-type diabetes, 103 were medium-sized, and 95 were heavy. In the clinical appearance of different parts of patients with diabetic microangiopathy, 70 were medium-sized, 72 were heavy. 24 hours urine hydroxyproline excretion, serum free hydroxyproline content and serum collagen-like protein binding