论文部分内容阅读
头孢呋肟属第二代头孢菌素,它的显著特点是对细菌产生的耐药酶的高度稳定性,不被葡萄球菌和大多数革兰阴性杆菌产生的β—内酰胺酶所破坏。因此是治疗耐药菌感染的重要选用药物;另外其肾毒性亦较第一代头孢菌素为低,使用安全。国外用于治疗敏感菌所致肺部感染,尿路感染和败血症等获良好疗效。本品国内尚无生产,进口品在应用中。本文研究该药的正常人药物代谢动力学,并拟订给药方案,提供国内临床合理用药的依据。
Ceftiofuril is a second-generation cephalosporin, which is distinguished by its high stability to bacterial-produced resistant enzymes and is not disrupted by β-lactamases produced by staphylococci and most Gram-negative bacteria. It is an important drug for the treatment of drug-resistant infections; In addition its nephrotoxicity is also lower than the first-generation cephalosporins, safe to use. Foreign for the treatment of sensitive bacteria caused by lung infections, urinary tract infections and sepsis and so have a good effect. This product is still no domestic production, imports in the application. This article studies the normal drug pharmacokinetics of the drug, and formulate drug programs, to provide the basis for clinical use of drugs.