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目的提高对遗传性非息肉病性大肠癌（ＨＮＰＣＣ）本质的认识。方法对１２个有遗传性非息肉病性大肠癌家族进行了回顾性分析。结果１２家族有３７例大肠癌患者，发病中位年龄为４４８岁，总计大肠癌灶４４处，其中结肠癌占６４％（２８／４４），位于脾曲以近的口侧段结肠内占５２％（２３／４４），大肠多原发癌占１１％（４／３７），有４个家族的子代患其它器官癌（３例胃癌、１例胆囊癌）占３３％（４／１２），全组病例未发现大肠息肉。结论对遗传性非息肉病性大肠癌患者及家族要进行严密监测，以便早期发现，及时治疗，争取较好的预后
Objective To improve the understanding of the nature of hereditary non-polyposis colorectal cancer (HNPCC). Methods We retrospectively analyzed 12 families with hereditary nonpolyposis colorectal cancer. Results There were 37 patients with colorectal cancer in the 12 family. The median age of onset was 44. 8 years old, and the total number of colorectal cancer was 44. Among them, colon cancer accounted for 64% (28/44). It was located in the colon of the oral and proximal segment of the spleen. 52% (23/44), multi-primary colorectal cancer accounted for 11% (4/37), and 4 families had descendants of other organ cancers (3 cases of gastric cancer, 1 case of gallbladder cancer) accounted for 33% (4/12 No colon polyps were found in the whole group. Conclusion The patients and hereditary patients with hereditary non-polyposis colorectal cancer should be closely monitored for early detection and timely treatment for better prognosis.