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目的探讨子宫肌瘤患者应用小剂量米非司酮治疗的效果。方法 94例子宫肌瘤患者为研究对象,均接受米非司酮治疗,以米非司酮所用剂量不同分为对照组(大剂量)及观察组(小剂量),各47例。比较两组患者的治疗效果。结果观察组治疗后孕酮(P)、雌二醇(E2)、黄体生成素(LH)、促卵泡激素(FSH)水平均低于对照组,差异具有统计学意义(P<0.05)。观察组治疗总有效率为93.62%,高于对照组的78.72%,差异具有统计学意义(P<0.05)。结论小剂量米非司酮治疗子宫肌瘤效果更佳,可有效纠正内分泌紊乱,改善临床症状,值得借鉴。
Objective To investigate the effect of low dose mifepristone treatment in patients with uterine fibroids. Methods A total of 94 patients with uterine fibroids were treated with mifepristone. The dosage of mifepristone was divided into control group (high dose) and observation group (low dose), 47 cases in each group. The treatment effect of two groups of patients was compared. Results The levels of progesterone (P), estradiol (E2), luteinizing hormone (LH) and follicle stimulating hormone (FSH) in the observation group were lower than those in the control group after treatment. The difference was statistically significant (P <0.05). The total effective rate of observation group was 93.62%, which was higher than 78.72% of control group, the difference was statistically significant (P <0.05). Conclusion Small doses of mifepristone treatment of uterine fibroids better, can effectively correct the endocrine disorders and improve clinical symptoms, it is worth learning from.