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本文目的在于观察丙酸睾丸酮(TP)对早孕妇女蜕膜组织孕、雌激素受体含量的影响并探讨TP增强前列腺素(PG)抗早孕效果的作用机理。41例正常早孕7—9周要求中止妊娠的妇女,分为实验组(15例)与对照组(26例)。前者于术前三天每日肌肉注射TP100mg共300mg。二组同时行负压吸引术。实验标本取自吸宫所得子宫壁蜕膜组织,分别测定孕、雌激素受体含量。结果表明,实验组与对照组相比,蜕膜细胞核内孕激素受体和雌激素受体含量均有显著性降低(P<0.001,P<0.01)。这提示:TP可能通过对抗雌激素,抑制和减少蜕膜孕酮受体合成的途径破坏早孕体内高内源性孕酮与其受体的正常结合进而影响了孕酮对蜕膜发育的维持,致使蜕膜变性或坏死脱落,从而增强了PG的抗早孕效果。
The purpose of this paper is to observe the effect of testosterone propionate (TP) on the levels of pregnancy and estrogen receptors in decidua in early pregnant women and to explore the mechanism of action of TP in enhancing the anti-early pregnancy effect of prostaglandin (PG). 41 cases of normal pregnancy 7-9 weeks require termination of pregnancy women, divided into experimental group (15 cases) and control group (26 cases). The former three days prior to intramuscular injection of TP100mg daily a total of 300mg. Two negative pressure suction at the same time. Experimental specimens were taken from the uterine wall of the decidual tissue of the sucking uterus to determine the pregnant and estrogen receptor contents respectively. The results showed that compared with the control group, the content of progesterone receptor and estrogen receptor in decidual nucleus of the experimental group were significantly decreased (P <0.001, P <0.01). This suggests that TP may prevent the normal combination of high endogenous progesterone and its receptor in early pregnancy by affecting estrogen, inhibiting and reducing the synthesis of decidual progesterone receptor, thereby affecting the maintenance of decidual development by progesterone Decidual degeneration or necrosis, thereby enhancing the anti-pregnancy effect of PG.