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目的:探讨脑梗死后血管性痴呆(VaD)的相关危险因素,为临床防治提供理论依据。方法:收集267例脑梗死患者的相关临床资料,其中包括55例VaD组和212例非VaD组,运用t检验、χ2检验和Logistic回归分析方法明确VaD的相关因素。结果:单因素分析表明年龄、低教育水平、高血压、糖尿病、房颤、脑卒中病史、多发性梗死、白质疏松、颞叶梗死在VaD组和对照组之间差异有统计学意义,并且白质疏松的严重程度越高越容易发生痴呆。经多因素Logistic回归分析证实高血压、白质疏松、多发性梗死、糖尿病和年龄在两组之间有显著统计学意义,是VaD的相关因素,并且其相关程度依次递减。结论:VaD是多种因素共同作用的结果,应予以针对性预防和及时的治疗,以便减少或延缓VaD的发生。
Objective: To explore the risk factors of vascular dementia (VaD) after cerebral infarction, and to provide a theoretical basis for clinical prevention and treatment. Methods: The clinical data of 267 patients with cerebral infarction were collected, including 55 cases of VaD group and 212 cases of non-VaD group. The related factors of VaD were determined by t test, χ2 test and Logistic regression analysis. Results: Univariate analysis showed that there was significant difference between VaD group and control group in terms of age, education level, hypertension, diabetes mellitus, atrial fibrillation, history of stroke, multiple infarction, leukoaraiosis and temporal lobe infarction. The greater the severity of loose more prone to dementia. Multivariate logistic regression analysis confirmed that hypertension, leukoaraiosis, multiple infarcts, diabetes mellitus and age were statistically significant between the two groups, which were the related factors of VaD, and their correlation degree decreased in turn. Conclusion: VaD is a result of many factors together and should be targeted prevention and timely treatment in order to reduce or delay the occurrence of VaD.