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目的探讨表皮生长因子受体（ＥＧＦＲ）在结直肠癌中的表达情况及其与病理特征和预后的关系。方法采用免疫组化ＳＰ法对有随访资料的５５例结直肠癌标本进行ＥＧＦＲ检测，结合图像分析观察判定结果。结果结直肠癌ＥＧＦＲ表达的阳性率为６９．０９％（３８／５５），ＥＧＦＲ的表达与肿瘤的浸润深度、淋巴结转移、Ｄｕｋｅ＇ｓ分期和生存期有关（Ｐ均＜０．０５），而与分化程度无关（Ｐ＞０．０５）。结论ＥＧＦＲ在结直肠癌的扩散和转移过程中可能产生一定的作用，并可作为预后判断的重要指标
Objective To investigate the expression of epidermal growth factor receptor (EGFR) in colorectal cancer and its relationship with pathological features and prognosis. Methods Immunohistochemical SP method was used to detect EGFR in 55 specimens of colorectal cancer with follow-up data. The results were combined with image analysis. Results The positive rate of EGFR expression in colorectal cancer was 69.09% (38/55). The expression of EGFR was related to the depth of tumor invasion, lymph node metastasis, Duke’s stage and survival (P < 0.05). It has nothing to do with the degree of differentiation (P>0.05). Conclusion EGFR may play a role in the proliferation and metastasis of colorectal cancer, and it can be used as an important indicator of prognosis.