论文部分内容阅读
目的探讨胚胎移植数目、年龄对IVF/ICSI-ET妊娠结局的影响。方法回顾性分析2012年1月1日至2012年6月30日在我院行IVF/ICSI-ET治疗的移植新鲜胚胎周期共704例,其中移植的第3天胚胎根据移植1、2、3枚胚胎分为1组、2组、3组,囊胚根据移植1枚、2枚胚胎分为A组、B组。分析分组后的临床妊娠率及多胎妊娠率;临床妊娠后分为单胎组、双胎组,再根据年龄分为≤35岁,>35岁两组,研究不同年龄组与妊娠时限、围产期并发症的关系、及对分娩孕周、分娩方式的影响。结果 (1)在704例移植新鲜胚胎周期中,1组与2组、3组有统计学差异,第2组与第3组的临床妊娠率,多胎妊娠率、异位妊娠率无统计学差异;在移植囊胚周期数目中A组与B组的临床妊娠率无统计学差异。(2)流产率分组:在≤35岁组,流产率、早期流产率无统计学差异,晚期流产率、早产率有统计学差异;>35岁组,流产率、晚期流产率无统计学差异,早产率有统计学差异。在≤35岁组,分娩周数、分娩方式有统计学差异。在>35岁组,分娩周数有统计学差异,分娩方式无统计学差异。结论在IVF治疗的不孕患者移植2枚、3枚胚胎,移植2枚囊胚可获得理想的妊娠率,但同时提高了多胎妊娠率的发生。年龄大于35岁组的临床妊娠流产率高于≤35岁组。双胎妊娠较单胎妊娠平均孕周减少,早产率高、剖宫产率高。
Objective To investigate the effect of embryo transfer number and age on IVF / ICSI-ET pregnancy outcome. Methods A total of 704 fresh embryos transferred from January 1, 2012 to June 30, 2012 in our hospital undergoing IVF / ICSI-ET were retrospectively analyzed. Embryos were divided into 1 group, 2 groups and 3 groups. According to the transplantation of 1 blastocyst, 2 embryos were divided into A group and B group. The clinical pregnancy rate and multiple pregnancy rate after grouping were analyzed. The clinical pregnancy was divided into single-fetus group and twin-fetus group. According to the age, the patients were divided into two groups of ≤35 years old and> 35 years old. The relationship between complications and gestational age, delivery mode of delivery. Results (1) In the 704 fresh embryo transfer cycles, there was a significant difference between group 1 and group 2 and group 3. There was no significant difference in clinical pregnancy rate, multiple pregnancy rate and ectopic pregnancy rate between group 2 and group 3 There was no significant difference in clinical pregnancy rates between group A and group B in the number of blastocyst cycles. (2) Miscarriage rate group: In the group of ≤35 years old, abortion rate, early miscarriage rate had no statistical difference, late miscarriage rate, premature birth rate had statistical difference;> 35 years old group, miscarriage rate, late miscarriage rate had no statistical difference , Preterm birth rate was statistically different. In ≤ 35 years old group, the number of delivery weeks, mode of delivery were statistically different. In> 35-year-old group, the number of delivery weeks were statistically different, mode of delivery was no significant difference. Conclusions Two infertile patients with IVF transplantation, three embryos and two blastocysts were transplanted to obtain the ideal pregnancy rate, but at the same time, the incidence of multiple pregnancy was increased. The clinical pregnancy abortion rate of patients older than 35 years old was higher than that of ≤35 years old group. Twin pregnancies than the average gestational age of singleton reduction, high rate of premature birth, cesarean section rate.