论文部分内容阅读
目的探讨瘦素基因nt+19A→G变异与阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的关系。方法采用PCR-RFLP方法,检测360例无亲缘关系的中国北方汉族居民的瘦素基因nt+19A→G基因型,其中OSAHS组180例,健康对照组180例。结果两组GG、GA、AA基因型及等位基因频率分布无统计学差异(P均>0.05);OS-AHS组各基因型个体的颈围、腹围、睡眠指标等均无统计学差异(P均>0.05)。结论瘦素基因nt+19A→G变异在北方汉族居民OSAHS的发生中可能无明显作用。
Objective To investigate the relationship between leptin gene nt + 19A → G mutation and obstructive sleep apnea-hypopnea syndrome (OSAHS). Methods PCR-RFLP was used to detect the nt + 19A → G genotype of 360 unrelated Han residents in northern China, including 180 OSAHS patients and 180 healthy controls. Results There was no significant difference in genotype and allele frequencies of GG, GA, AA between the two groups (P> 0.05). There was no significant difference in neck circumference, abdominal circumference and sleep index among all genotypes in OS-AHS group (P> 0.05). Conclusion The nt + 19A → G mutation of leptin gene may not play a significant role in the pathogenesis of OSAHS in northern Han Chinese.