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目的分析和研究低剂量干扰素治疗丙肝肝硬化临床效果及相关影响因素。方法 48例丙肝肝硬化患者,随机分为观察组与对照组,各24例。对照组患者给予常规治疗,观察组患者在常规治疗基础上加用低剂量干扰素治疗,比较两组患者治疗12个月疗效及不良反应发生率。结果治疗12个月后观察组血清纤维化各项指标检测值均低于对照组,差异有统计学意义(P<0.05)。观察组治疗期间不良反应发生率高于对照组,差异有统计学意义(P<0.05)。结论将低剂量干扰素应用于丙肝肝硬化患者治疗中,其能够有效改善患者肝功能,延缓患者病情发展,虽然不良反应发生率较高,但经对症处理后均可得到缓解,对治疗未产生影响,值得临床借鉴与推广。
Objective To analyze and study the clinical effect of low-dose interferon on hepatitis C cirrhosis and related influencing factors. Methods 48 cases of hepatitis C cirrhosis patients were randomly divided into observation group and control group, 24 cases in each. The patients in the control group were given routine treatment. The patients in the observation group were treated with low-dose interferon on the basis of routine treatment. The curative effect and the incidence of adverse reactions in both groups were compared at 12 months. Results After 12 months treatment, the serum fibrosis indexes in the observation group were lower than those in the control group (P <0.05). The incidence of adverse reactions in the observation group was higher than that in the control group, the difference was statistically significant (P <0.05). Conclusion Low-dose interferon can be used to treat patients with hepatitis C cirrhosis, which can effectively improve liver function and delay the development of patients’ condition. Although the incidence of adverse reactions is high, it can be relieved after symptomatic treatment, Influence, it is worth learning and promotion.