匹格列酮对2型糖尿病炎症标志物的影响研究

• 作 者: 孔宪如 董吉祥 徐志刚 史光英
• 机 构: 镇江市第一人民医院内分泌科,苏州大学附属第二医院内分泌科,镇江市第一人民医院内分泌科,镇江市第一人民医院内分泌科 212002,212002,212002
• 出 处: 江苏医药
• 发表日期: 2004年09期
• 关键词: 匹格列酮 炎症因子 2型糖尿病

目的 研究胰岛素增敏剂-匹格列酮在2型糖尿病中的抗炎作用。方法 选择健康成人20例(对照组),2型糖尿病35例(糖尿病组),测定两组人群C反应蛋白(CRP)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)、白细胞计数(WBC),观察炎症因子水平的差异;糖尿病组使用匹格列酮治疗12周,观察治疗前后各炎症因子水平的变化。结果 糖尿病组炎症因子水平较对照组明显升高,差异有显著性(P<0.001);经匹格列酮治疗后CRP、TNF-α、WBC水平下降明显(P<0.01),且该作用与血糖下降程度无关。结论 匹格列酮对2型糖尿病具有明显的抗炎作用,且抗炎作用不依赖于血糖下降。

Objective To study the antiinflammatory effect of insulin sensitizer - pioglitazone in type 2 diabetes mellitus. Methods Twenty healthy adults (control group) and 35 type 2 diabetes mellitus (diabetic group) were selected. The levels of C reactive protein (CRP), interleukin 6 (IL-6) and tumor necrosis factor alpha ) And white blood cell count (WBC). The levels of inflammatory cytokines were observed. The diabetic group was treated with pioglitazone for 12 weeks. The levels of inflammatory cytokines were observed before and after treatment. Results The levels of inflammatory cytokines in diabetic group were significantly higher than those in control group (P <0.001). The levels of CRP, TNF-α and WBC decreased significantly after treatment with pioglitazone (P <0.01) The degree of decline in blood glucose has nothing to do. Conclusion Pioglitazone has obvious anti-inflammatory effect on type 2 diabetes mellitus, and its anti-inflammatory effect does not depend on the drop of blood sugar.