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Objective: To investigate the relationship between matrix metalloproteinase-2 (MMP-2), MMP-9 as well as microvessel density (MVD) and their clinicopathological features in gastric cancer. Methods: The expression of MMP-2,MMP-9 and MVD were detected by immunohistochemistry SP method on 65 cases of gastric cancer tissue and 32 adjacent gastric mucosa. Results: The positive expression of MMP-2, MMP-9 and MVD in cancer group were significantly higher than those of adjacent mucosa group (P＜0.01). The positive expression of MM P-2 and MMP-9 had closely correlation with clinical features of lymphatic metastasis, pathological type and stages (P＜0.05), and the high level of CD 34 had correlation with metastasis and stages (P＜0.01). The positive expression of MMP-2 and MMP-9 showed significant correlation with the level of MVD. Prognosis was mostly affected by lymphatic metastasis and stages of clinical features. The low cum survival rate was showed in the groups of positive expression of MMP-2, MMP-9 and high level of MVD. Conclusion: MMP-2,MMP-9 and MVD play an important role in metastases, invasion and prognosis of gastric cancer, which is a valuable maker to evaluate the prognosis.