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住院病人常同时接受多种药物治疗,药物相互作用也就难以避免,同时使用6～10种药物治疗的病人,有7%的可能发生药物相互作用;而同时使用10～20种药物治疗时,这种可能性上升为40%,麻醉药物的使用,又使药物相互作用的可能性大大增加。药物相互作用的机理药物制剂可改变药效。如 PH 为10.5的2.5%硫喷妥钠水溶液与 pH 值较低的阿片类药物混合时将沉淀。虽然药液透明表现无药物相互作用发生,但药物也许发生了降解而失活,例如 Amrinone(正性肌力药)溶解于含葡萄糖的溶液中可失去药效。药物在体内通过药代动力学和药效动力
Hospitalized patients often receive multiple medications at the same time, drug interactions will be difficult to avoid, while the use of 6 to 10 kinds of drug treatment of patients, 7% of the possible drug interactions; while using 10 to 20 kinds of drug treatment, This possibility rises to 40% and the use of narcotic drugs increases the likelihood of drug interactions. The mechanism of drug interaction Pharmaceutical formulations can change the efficacy. For example, a 2.5% sodium thiopental solution at a pH of 10.5 will precipitate when mixed with a lower pH opioid. Although the drug solution does not show any drug interactions due to its transparent appearance, the drug may be degraded and inactivated. For example, Amrinone can lose its efficacy when dissolved in a glucose-containing solution. Drugs pass pharmacokinetics and pharmacodynamics in the body