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合成了2个新的配合物:[Cu(NFA)(TBZ)(H2O)](NO3).(H2O)0.5(1)和[Cu(NFA)(HPB)(H2O)]NO3(2)[NFA=1-乙基-6-氟-1,4-二氢-4-氧代-7-(哌嗪-1-基)-3-喹啉羧酸(诺氟沙星),TBZ=2-(噻唑-4′-基)苯并咪唑,HPB=2-(吡啶-2-基)-苯并咪唑]。用元素分析、摩尔电导率、红外光谱和紫外可见光谱等方法对配合物进行了表征;通过二倍稀释法研究了配合物对枯草杆菌、大肠杆菌和沙门氏菌的抑制作用;用电子吸收光谱、荧光光谱和粘度测定等方法研究了配合物与CT-DNA的作用。结果表明,这2种配合物均具有良好的抗菌活性,能以插入方式与CT-DNA结合,且抗菌活性与DNA结合能力大小一致:配合物2>1。
Two novel complexes were synthesized: [Cu (NFA) (TBZ) (H2O)] (NO3). (H2O) 0.5 (1) and [Cu (NFA) NFA = 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7- (piperazin- 1 -yl) -3-quinolinecarboxylic acid (norfloxacin), TBZ = 2 - (thiazol-4’-yl) benzimidazole, HPB = 2- (pyridin-2-yl) -benzimidazole]. The complex was characterized by elemental analysis, molar conductivity, infrared spectrum and UV-visible spectrum. The inhibitory effect of the complex on Bacillus subtilis, Escherichia coli and Salmonella was studied by double dilution method. The electron absorption spectra, fluorescence Spectroscopy and viscosity determination methods such as the role of the CT-DNA complexes. The results show that these two complexes have good antibacterial activity, can be inserted with the CT-DNA binding, and antibacterial activity and DNA binding capacity of the same size: complex 2> 1.