论文部分内容阅读
Wound healing impairment represents a particularly challenging clinical problemto which no efficacious treatment regimens currently exist.The factors ensuringappropriate intercellular communication during wound repair are not completelyunderstood.Although protein-type mediators are well-established players in thisprocess,emerging evidence from both animal and human studies indicates thatnitric oxide (NO) plays a key role in wound repair.The beneficial effects of NO onwound repair may be attributed to its functional influences on angiogenesis,inflammation,cell proliferation,matrix deposition,and remodeling.Recent find-ings from in vitro and in vivo studies of NO on wound repair are summarized inthis review.The unveiled novel mechanisms support the use of NO-containingagents and/or NO synthase gene therapy as new therapeutic regimens for im-paired wound healing.
Wound healing impairment represents a particularly challenging clinical problem that which no efficacious treatment regimens currently exist. The factors ensuringappropriate intercellular communication during wound repair are not completelyunderstood. Although protein-type mediators are well-established players in this process, emerging evidence from both animal and human studies indicates that nitric oxide (NO) plays a key role in wound repair. The beneficial effects of NO onwound repair may be attributed to its functional influences on angiogenesis, inflammation, cell proliferation, matrix deposition, and remodeling. in vivo studies of NO on wound repair are summarized in this review. The unveiled novel mechanisms support the use of NO-containing agents and / or NO synthase gene therapy as new therapeutic regimens for im-paired wound healing.