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环孢菌素虽可延长异体小肠移值后的存活期,但其效果不及肝、肾和皮肤的移植。为此,作者对异体小肠移前预给放射处理,观察其效果。取成年犬60条,按相同条件配对,分别作受体犬和供体犬。除保留8 cm空肠和回肠外,切除全部小肠,移植相等长度的异体小肠。在实验组移植前,异体小肠置于塑料袋内,放在冰块中,分别经直线加速器照射750、1500或2500 rads,每组配5条对照犬,不给放射处理。移植后第一天起,给环孢菌素10 mg/kg静脉注射,共14天,随给口服剂量20 mg/kg。移植时以及移植后6、12、26和40周作肠系膜
Although cyclosporine can extend the survival of allogeneic small bowel transplantation, but its effect is less than the liver, kidney and skin transplantation. To this end, the author of allogeneic small intestine pre-given radiation treatment, to observe the effect. Take 60 adult dogs, paired according to the same conditions, respectively, for the recipient dogs and donor dogs. In addition to retaining the 8 cm jejunum and ileum, the entire small intestine was resected and allograft intestines of equal length were transplanted. Before the experimental group was transplanted, allogeneic small intestine was placed in a plastic bag, placed in ice cubes and irradiated with 750,1500 or 2,500 rads by a linear accelerator respectively. Each group was provided with 5 control dogs, and no radiotherapy was given. From the first day after transplantation, cyclosporin 10 mg / kg was administered intravenously for 14 days with an oral dose of 20 mg / kg. Mesentery was performed at 6, 12, 26 and 40 weeks after transplantation