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目的探讨曲美他嗪对老年冠心病不稳定型心绞痛患者的临床疗效。方法选择65岁以上冠心病不稳定型心绞痛患者132例,按随机数字表法随机分为治疗组(68例)和对照组(64例)。2组均给予常规抗心绞痛药物(β受体阻滞剂、钙离子拮抗剂、血管紧张素转化酶抑制剂、硝酸盐制剂及抗血小板药物)治疗,治疗组在此基础上加用曲美他嗪。共治疗4周。观察2组患者治疗前后的临床症状、硝酸甘油用量及心电图ST段改变。结果 2组治疗均能缓解患者临床症状。治疗后治疗组心绞痛的发作次数和硝酸甘油的消耗量以及心电图改善均较对照组明显(P<0.05或P<0.01)。但2组治疗后的血压、心率差异无统计学意义(P均>0.05)。结论曲美他嗪能减轻心绞痛症状,改善心肌缺血,对老年不稳定型心绞痛临床效果较好。
Objective To investigate the clinical efficacy of trimetazidine in senile patients with unstable angina pectoris. Methods 132 patients with unstable angina pectoris over 65 years of age were randomly divided into treatment group (68 cases) and control group (64 cases) according to the random number table method. Both groups were given conventional anti-anginal drugs (β-blockers, calcium antagonists, angiotensin-converting enzyme inhibitors, nitrates and antiplatelet drugs) treatment group based on the use of trimetazidine Oxazine. A total of 4 weeks treatment. The clinical symptoms, the amount of nitroglycerin and the ST segment of ECG were observed before and after treatment in two groups. Results The two groups of patients can relieve clinical symptoms. The number of episodes of angina pectoris, the consumption of nitroglycerin and the improvement of electrocardiogram in the treatment group were significantly higher than those in the control group (P <0.05 or P <0.01). However, there was no significant difference in blood pressure and heart rate between the two groups (all P> 0.05). Conclusion Trimetazidine can relieve the symptoms of angina pectoris, improve myocardial ischemia and has better clinical effect on unstable angina pectoris.