论文部分内容阅读
目的探讨高剂量左氧氟沙星在重症监护室医院获得性肺炎治疗中的临床疗效。方法鄂州二医院重症监护室收治获得性肺炎患者110例,将其按照分组法随机分为,高剂量组和低剂量组,每组各55例,高剂量组患者静脉滴注左氧氟沙星注射液500 mg,低剂量组静脉滴注左氧氟沙星注射液400 mg。治疗结束后对疗效和不良反应进行分析。结果高剂量组和低剂量组的有效率分别为90.11%和63.64%,两组比较差异有统计学意义(P<0.05);高剂量和低剂量组的显效时间分别为(3.1±1.3)d和(4.3±2.0)d,两组的疗程分别为(7.1±2.6)d和(10.4±3.2)d,两组比较差异有统计学意义(P<0.05);两组的不良反应发生率比较差异无统计学意义(P>0.05)。结论高剂量左氧氟沙星在重症监护室治疗获得性肺炎治疗中疗效显著,安全性好,值得临床推广使用。
Objective To investigate the clinical efficacy of high-dose levofloxacin in hospital-acquired pneumonia in intensive care unit. Methods One hundred and ten patients with acquired pneumonia were admitted to intensive care unit of Ezhou Second Hospital. They were randomly divided into high dose group and low dose group according to the grouping method, 55 cases in each group. The patients in high dose group were given intravenous infusion of levofloxacin 500 mg , Low-dose intravenous infusion of levofloxacin 400 mg. After treatment, the efficacy and adverse reactions were analyzed. Results The effective rates of high-dose and low-dose groups were 90.11% and 63.64%, respectively, with significant difference between the two groups (P <0.05). The effective time of high-dose and low-dose groups were (3.1 ± 1.3) d And (4.3 ± 2.0) days respectively. The duration of treatment was (7.1 ± 2.6) days and (10.4 ± 3.2) days in both groups, with significant difference between the two groups (P <0.05). The incidence of adverse reactions The difference was not statistically significant (P> 0.05). Conclusion High-dose levofloxacin has significant curative effect in the treatment of acquired pneumonia in intensive care unit, which is safe and worthy of clinical promotion.