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目的观察慢性心力衰竭(chronic heart failure,CHF)患者给予综合干预对疾病进展的影响。方法选择2014年6月—2015年5月收治的80例慢性CHF患者作为研究对象,随机分为对照组和干预组各40例。对照组给予常规药物治疗,干预组制定针对性干预计划,按计划进行早期干预。分别于入组时及干预后12个月观察两组左室射血分数(left ventricular ejection fraction,LVEF)、左室舒张末期内径(left ventricular end-diastolic dimension,LVEDD)等心功能指标、生活质量评分及急性发作需治疗次数等指标的变化情况。计量资料组间比较采用t检验,组内比较采用配对t检验,P<0.05为差异有统计学意义。结果干预后12个月,干预组LVEF、LVEDD、发作次数、生活质量评分分别为(56.78±8.12)%、(48.90±4.09)mm、(0.79±1.12)次、(9.34±3.12)分,与入组时的(41.67±6.78)%、(55.78±5.45)mm、(1.32±1.10)次、(19.98±4.12)分比较差异均有统计学意义(均P<0.05)。干预后12个月,干预组LVEF、LVEDD、发作次数、生活质量评分与对照组的(43.89±5.56)%、(55.78±5.07)mm、(1.56±1.23)次、(19.89±6.12)分比较差异均有统计学意义(均P<0.05)。结论早期行为干预可明显减缓慢性CHF患者疾病发展,提高生活质量。
Objective To observe the effect of comprehensive intervention on disease progression in patients with chronic heart failure (CHF). Methods Eighty patients with chronic CHF admitted from June 2014 to May 2015 were enrolled in this study. They were randomly divided into control group (n = 40) and intervention group (n = 40). Control group was given conventional drug treatment, intervention group to develop targeted intervention plan, according to the plan for early intervention. The left ventricular ejection fraction (LVEF), left ventricular end-diastolic dimension (LVEDD) and other cardiac function parameters were measured at admission and at 12 months after intervention. The quality of life Score and the number of acute attacks need to be treated and other indicators of change. Measurement data were compared between groups using t test, the group was compared using paired t test, P <0.05 for the difference was statistically significant. Results The scores of LVEF, LVEDD, number of seizures and quality of life in the intervention group were (56.78 ± 8.12)%, (48.90 ± 4.09) mm, (0.79 ± 1.12) and (9.34 ± 3.12), respectively (41.67 ± 6.78)%, (55.78 ± 5.45) mm, (1.32 ± 1.10) and (19.98 ± 4.12) points at the time of enrollment. There were significant differences between the two groups (all P <0.05). At 12 months after intervention, LVEF, LVEDD, number of seizures and quality of life in intervention group were significantly lower than those in control group (43.89 ± 5.56)%, (55.78 ± 5.07) mm, (1.56 ± 1.23) and (19.89 ± 6.12) The differences were statistically significant (all P <0.05). Conclusion Early behavioral intervention can significantly slow down the development of chronic CHF patients and improve their quality of life.