论文部分内容阅读
近年来才认识到吸烟是影响药物代谢的重要因素之一。烟草上多环香烃有很强的酶诱导作用,如果以克分子量计算,其诱导作用比众所周知的苯巴比妥还要强得多。吸烟者茶碱、咖啡因,丙米嗪和镇痛新的代谢显著增快,而对安定、去甲替林、苯妥英钠、杜冷丁与酒精等的主要生物转换途径无明显影响,因而其药物代谢酶是选择性增高的。作者报告一例精神分裂症患者的吸烟情况和氯
In recent years, it has been realized that smoking is one of the important factors that affect drug metabolism. Tobacco polycyclic aromatic hydrocarbons have a strong enzyme-induced role, if calculated in grams, its induction than the well-known phenobarbital is still much stronger. Smokers, theophylline, caffeine, imipramine and the new metabolites of analgesic significantly increased, but no significant effect on the main biotransformation pathway of diazepam, nortriptyline, phenytoin sodium, pethidine and alcohol, and therefore its drug Metabolic enzymes are selectively increased. The authors report a case of smoking and chlorine in schizophrenic patients