Accelerated tooth movement in Rsk2-deficient mice with impaired cementum formation

• 作 者: Cita Nottmeier Maximilian G.Decker Julia Luther Simon von Kroge B?rbel Kahl-Nieke Michael Amling Thorsten Schinke Julian Petersen Till Koehne
• 机 构: Department of Orthodontics,University Medical Center Hamburg-Eppendorf,Hamburg,Germany;Institute of
• 出 处: 国际口腔科学杂志（英文版）
• 发表日期: 2020年4期

INTRODUCTIONrnThe growth factor regulated ribosomal S6 kinase RSK2 (RPS6KA3) belongs to a group of widely expressed serine/threonine kinases, that are important for growth, survival, and proliferation of cells.1–3 RSK2 operates at the distal end of the Ras/Map kinase pathway and phosphorylates different substrates, such as cAMP response element-binding protein (CREB), c-Fos, activating transcription factor 4 (ATF4), and estrogen receptor alpha (ERα).4–6 CREB, ATF4, and ERα are known to induce differentiation of bone-forming osteoblasts,4,7–12 whereas c-Fos is required for differentiation of bone-resorbing osteoclasts.13 RSK2, therefore, plays a pivotal role in bone turnover.