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目的探讨早孕期孕妇血清ADAM12-S水平与自然流产的相关性。方法应用时间分辨荧光免疫分析法检测早孕期(8~11周)孕妇血清中ADAM12-S水平,测定范围是18~1 503μg/L,并分析ADAM12-S水平变化与自然流产等妊娠结局的关系。结果正常单胎孕妇血清中ADAM12-S水平随孕周的增加而增加,自然流产孕妇血清ADAM12-S水平明显低于正常单胎孕妇,差异有统计学意义(P<0.05)。结论早孕期孕妇血清ADAM12-S水平检测可预测早期妊娠丢失,在异常妊娠检测方面有较大的临床价值。
Objective To investigate the correlation between serum ADAM12-S levels and spontaneous abortion in pregnant women in early pregnancy. Methods The serum levels of ADAM12-S in pregnant women during the first trimester (8-11 weeks) were determined by time-resolved fluorescence immunoassay. The range of ADAM12-S was 18-1 503μg / L. The relationship between ADAM12-S levels and pregnancy outcomes such as spontaneous abortion . Results The level of ADAM12-S in normal singleton pregnant women increased with gestational age. The level of ADAM12-S in spontaneous abortion pregnant women was significantly lower than that in normal pregnant women (P <0.05). Conclusion The detection of serum ADAM12-S in early pregnant women can predict the loss of early pregnancy, and has great clinical value in the detection of abnormal pregnancy.