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目的观察比较难治性贫血(MDS-RA)与巨幼细胞性贫血(MA)的骨髓形态检验方法及结果,总结其临床意义。方法选取我院2009年5月至2011年5月难治性贫血患者31例和巨幼细胞性贫血的患者34例,观察比较两组患者的骨髓形态学检验结果。结果两组血常规检验中,MDS-RA组以白细胞和血红蛋白减少、血小板和血红蛋白减少所占比例明显高于MA组,全血细胞减少、MCV>100fl、幼红幼粒细胞所占比例明显低于MA组,两组比较差异有统计学意义(P<0.05)。结论MDS-RA与MA患者在病态造血方面有相似之处,前者的诊断需要结合病态造血的情况进行综合分析,后者的诊断则多以骨髓形态学的红系巨变为主,若形态学诊断存在困难,可辅以其他实验室检验进行鉴别诊断,具有重要的临床意义。
Objective To observe and compare the bone marrow morphology test results of refractory anemia (MDS-RA) and megaloblastic anemia (MA), and summarize its clinical significance. Methods Totally 31 patients with refractory anemia and 34 patients with megaloblastic anemia in our hospital from May 2009 to May 2011 were selected and bone marrow morphology test results were compared between the two groups. Results In the two groups of blood tests, the percentage of leucocyte and hemoglobin in MDS-RA group decreased, while the proportion of platelet and hemoglobin decreased significantly in MDS-RA group compared with MA group. The percentage of young erythroblasts was significantly lower than that of MA group MA group, the difference between the two groups was statistically significant (P <0.05). Conclusions MDS-RA and MA patients have similarities in morbid hematopoiesis. The diagnosis of the former needs to be combined with the analysis of morbid hematopoiesis. The diagnosis of the latter is mainly erythroid changes of the marrow morphology. If the morphological diagnosis There are difficulties, can be supplemented by other laboratory tests for differential diagnosis, has important clinical significance.