论文部分内容阅读
关于过氧化物歧化酶(SOD)在动物体内的作用了解的很少。从放射生物学的观点,SOD是值得注意的。由于游离的OH自由基再结合而清除射解过程中形成的过氧化物自由基,在这一过程中SOD可能有意义。被SOD催化的反应产生过氧化氢,2O_2~-+2H~+→O_2+H_2O_2。过氧化氢是SOD的抑制剂,但在生理条件下被过氧化氢酶所反映。SOD作为天然放射防护剂还有争论。过去的研究发现SOD的冰冻干燥制剂在空气中受50千伦剂量~(60)Co丙线照射后,活性丢失20％左右。Roberts等在缺氧条件下,以同样的剂量照射SOD的稀水
Little is known about the role of superoxide dismutase (SOD) in animals. From the radiobiology point of view, SOD is noteworthy. Due to the recombination of free OH radicals to clear the peroxide radicals formed during the radiolysis, SOD may be of interest in this process. The reaction catalyzed by SOD produces hydrogen peroxide, 2O_2 ~ - + 2H ~ + → O_2 + H_2O_2. Hydrogen peroxide is an inhibitor of SOD but is reflected by catalase under physiological conditions. There is also debate about SOD as a natural radioprotectant. In the past, it was found that freeze-dried preparations of SOD lost about 20% of their activity when exposed to 60,000 Co in the air. Roberts and other hypoxic conditions, the same dose of water irradiation SOD