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目的 :观察帕罗西汀治疗肠易激综合征 (IBS)的疗效。方法 :78例符合罗马Ⅱ诊断标准的肠易激综合征患者被随机分为帕罗西汀治疗组 (n =3 8)和对照组 (n =40 )。两组均根据患者不同症状进行对症处理 ,如解痉剂、止泻剂或胃肠动力促进剂。帕罗西汀治疗组加用帕罗西汀片 2 0mg ,早餐时顿服。疗程 8周。分别于 8周末记录症状改善情况。结果 :同对照组相比 ,帕罗西汀治疗IBS的疗效明显 ,其在缓解患者腹痛 ,腹泻方面显示很好的疗效 (P <0 0 5 )。结论 :帕罗西汀能明显改善患者胃肠道症状。
Objective: To observe the efficacy of paroxetine in the treatment of irritable bowel syndrome (IBS). Methods: A total of 78 patients with irritable bowel syndrome who met the diagnostic criteria of Rome Ⅱ were randomly divided into paroxetine group (n = 38) and control group (n = 40). Two groups were symptomatic treatment based on different symptoms of patients, such as antispasmodic agents, antidiarrheal agents or gastrointestinal motility agents. Paroxetine treatment group with paroxetine tablets 20mg, Dayton breakfast service. Treatment for 8 weeks. At the end of the 8th week, symptom improvement was recorded. Results: Compared with the control group, the efficacy of paroxetine in the treatment of IBS was significant, which showed good efficacy in relieving abdominal pain and diarrhea in patients (P <0.05). Conclusion: Paroxetine can significantly improve gastrointestinal symptoms in patients.