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N-甲基-D-天冬氨酸(NMDA)受体是包含谷氨酸和甘氨酸结合位点的离子通道,在中枢神经系统的突触传递和突触可塑性调节中起重要作用。已证实的3种NMDA亚基,在体内有着不同的分布和功能。抗NMDA受体脑炎是近年才被确认的好发于年轻女性的可治疗的疾病,其临床特点为精神病性脑病、癫样发作以及躯干和面部的异常运动,特别是下颌关节肌张力异常。近年儿童抗NMDA受体脑炎有逐渐增多趋势。因此,增加对典型临床表现的认识,可提高对本病的早期识别并给予适当的治疗。
The N-methyl-D-aspartate (NMDA) receptor, an ion channel that contains glutamate and glycine binding sites, plays an important role in synaptic transmission and synaptic plasticity in the central nervous system. The three NMDA subunits have been proven to have different distributions and functions in the body. Anti-NMDA receptor encephalitis is a treatable disease that has been identified in recent years as a treatable condition in young women. It is characterized by psychogenic encephalopathy, epileptic seizures, and abnormal movements of the trunk and face, especially abnormalities in mandibular joint dystonia . In recent years, children with anti-NMDA receptor encephalitis have gradually increased. Therefore, to increase awareness of the typical clinical manifestations can improve the early identification of the disease and give appropriate treatment.