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报告1例坏疽性脓皮病合并炎症性肠病。患者男,30岁。腹痛、腹泻及稀薄脓血便1个月余;躯干及四肢出现散在的红色丘疹、脓疱疹,溃疡伴疼痛12 d入院。皮损组织病理检查:表皮角化过度,棘层增厚,真皮全层及皮下脂肪间大量中性粒细胞浸润,可见红细胞外渗及血管壁纤维蛋白样变性。电子肠镜诊断为炎症性肠病。抗核周型中性粒细胞胞质抗体(anti perinuclear antineutrophil cytoplasmic antibody,p-ANCA)阳性。予糖皮质激素、美沙拉嗪及支持治疗后,患者病情明显好转。
Report of 1 case of pyoderma gangrenosum with inflammatory bowel disease. Male patient, 30 years old. Abdominal pain, diarrhea and thin purulent blood more than 1 month; trunk and limbs scattered scattered red papules, impetigo, ulcer with pain 12 d admission. Skin lesions histological examination: epidermal hyperkeratosis, stratum spinosum, full-thickness dermis and subcutaneous fat mass neutrophil infiltration, visible red blood cell extravasation and vascular wall fibrosis. Electronic colonoscopy diagnosed as inflammatory bowel disease. Anti-perinuclear antineutrophil cytoplasmic antibody (p-ANCA) positive. To glucocorticoid, Mesalazine and supportive treatment, the patient’s condition improved significantly.