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目的探讨结核性脑膜炎(TBM)治疗前后脑脊液(CSF)的变化及其对临床诊断的意义。方法回顾性分析2009~2011年南京脑科医院确诊的42例TBM患者治疗前、治疗后1周及治疗后2周CSF各指标的动态变化。结果与治疗前比较,治疗后第二周CSF各指标大部分有显著变化(P<0.05)。治疗后第2周CSF各指标较治疗后第1周虽有变化,但大部分无明显差异,仅中性粒细胞百分比、免疫白蛋白及免疫球蛋白两项指标差异明显(P<0.05)。结论 TBM治疗前后CSF各指标变化明显,对于诊断有重要参考意义。
Objective To investigate the changes of cerebrospinal fluid (CSF) in patients with tuberculous meningitis (TBM) before and after treatment and its clinical significance. Methods The dynamic changes of CSF in 42 TBM patients diagnosed in Nanjing Brain Hospital from 2009 to 2011 were retrospectively analyzed before treatment, 1 week after treatment and 2 weeks after treatment. Results Compared with those before treatment, most of the indexes of CSF in the second week after treatment had significant changes (P <0.05). The indexes of CSF in the second week after treatment were different from those in the first week after treatment, but most of them had no significant difference. Only the percentage of neutrophil, immune albumin and immunoglobulin had significant difference (P <0.05). Conclusion The indexes of CSF before and after TBM change obviously, and have important reference value for diagnosis.