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在化学方面,甲醋唑胺(Methazolamide)是和乙酰唑胺有密切关系的一种碳酸酐酶抑制剂,具有某种有利的药理学特性。大约45％的血浆甲醋唑胺没有与血浆蛋白结合。因此,易于弥散到组织中去;而乙酰唑胺仅有7％是游离的。此外,甲醋唑胺的血浆半衰期大约是乙酰唑胺的3倍。在正常人,甲醋唑胺的口服剂量低到25mg,每日3次,其血浆的药物浓度等于需要降低兔子眼压的浓度。此外,最低的血浆甲醋唑胺浓度对肾脏的影响很小,这是根据血浆中二氧化碳和尿中枸橼酸盐的变化来决定的。与此对比,乙酰唑
Chemically, Methazolamide is a carbonic anhydrase inhibitor closely related to acetazolamide and has some favorable pharmacological properties. Approximately 45% of plasma Methazolamide does not bind to plasma proteins. As a result, it is easy to diffuse into the tissue; whereas only 7% of acetazolamide is free. In addition, the plasma half-life of methazolamide is about 3 times that of acetazolamide. In normal subjects, oral doses of methazolamide are as low as 25 mg, 3 times a day, and their plasma drug concentration equals the need to lower the intraocular pressure in rabbits. In addition, the lowest plasma concentration of methazolamide has little effect on the kidneys, which is based on changes in plasma carbon dioxide and urinary citrate. In contrast, acetozole