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作者对1250例人工流产的胚胎进行了染色体分析的结果,得知母体在妊娠初期服用各种药物,可诱发染色体畸变。在人外周血培养液里加入解热、止痛药时,也获得了染色体结构异常有所增加的印象。此外,我们还看到了各种药物引起染色体异常的报告。现选取临床常用的巴比妥类对胚胎的影响作为动物模型进行观察。方法:以3—6个月龄的雌金色田鼠80只供实验。为了调整动物的性周期,通过人工照明,使饲养室昼夜颠倒过来。然后根据每天上午九时检查有无粘液性阴道排出物和特有姿势(脊柱前弯)来判断雌鼠是否发情。使发情雌鼠同健康雄鼠在约30分钟内进行交
The author of 1250 cases of abortion embryos were analyzed by chromosome results that the mother in the early pregnancy taking a variety of drugs, can induce chromosomal aberrations. In the human peripheral blood culture solution to add antipyretics, painkillers, also obtained an increase in chromosomal abnormalities impression. In addition, we have also seen reports of chromosomal abnormalities caused by various drugs. Now choose the effect of commonly used barbiturates on embryos as an animal model. Methods: Eighty-three female golden-field mice aged 3-6 months were used for experiments. In order to adjust the animal’s sexual cycle, artificial lighting, so that breeding room upside down day and night. Then according to the daily check at 9:00 am whether there is mucinous vaginal discharge and peculiar posture (pronation) to determine whether female estrus. So that estrous females with healthy male rats in about 30 minutes to pay