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目的探讨测定阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血清瘦素水平的临床意义。方法选择年龄、性别差异无统计学意义的肥胖OSAHS患者65例(肥胖OSAHS组)、非肥胖OSAHS患者39例(非肥胖OSAHS组)、单纯肥胖患者13例(肥胖对照组)和健康人22名(正常对照组)进行多导睡眠图(PSG)监测,用放射免疫法测定所有对象的血清瘦素水平。结果肥胖OSAHS组血清瘦素水平(17.85±7.86)ng/L较非肥胖OSAHS组(13.42±6.11)ng/L增高(P<0.01);肥胖OSAHS及非肥胖OSAHS组血清瘦素较肥胖对照组(12.25±4.72)ng/L、正常对照组(7.86±2.02)ng/L增高(P<0.05或0.01)。OSAHS患者血清瘦素水平较对照组升高(F=7.01,P<0.01),肥胖患者血清瘦素水平较非肥胖者升高(F=17.38,P<0.01),肥胖与OSAHS无交互作用(F=1.44,P>0.05)。血清瘦素水平与体重指数(BMI)、微觉醒指数(MAI)、呼吸暂停低通气指数(AHI)、氧减指数(ODI4)呈正相关(r=0.39、0.17、0.24、0.24,P<0.01或0.05)。结论OSAHS患者、肥胖患者血清瘦素水平增高,除肥胖因素外,OSAHS本身也是引起瘦素水平升高的原因。
Objective To investigate the clinical significance of serum leptin levels in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). Methods Sixty-five obese OSAHS patients (obese OSAHS group), 39 nonobese OSAHS patients (nonobese OSAHS group), 13 obesity patients (obese control group) and 22 healthy individuals (Normal control group) for polysomnography (PSG) monitoring, and radioimmunoassay was used to determine the level of serum leptin in all subjects. Results Serum leptin levels in obese OSAHS group were significantly higher than those in obese OSAHS group (17.85 ± 7.86 ng / L vs 13.42 ± 6.11 ng / L, P <0.01) (12.25 ± 4.72) ng / L and normal control group (7.86 ± 2.02) ng / L respectively (P <0.05 or 0.01). The level of serum leptin in OSAHS patients was higher than that in control group (F = 7.01, P <0.01), the level of serum leptin in obese patients was higher than that in non-obese patients (F = 17.38, P <0.01) F = 1.44, P> 0.05). Serum leptin levels were positively correlated with BMI, MAI, AHI and ODI4 (r = 0.39,0.17,0.24,0.24, P <0.01 or 0.05). Conclusion OSAHS patients, obese patients with elevated serum leptin levels, in addition to obesity, OSAHS itself is the cause of elevated leptin levels.