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Ｔ细胞需两种以上刺激信号才能充分活化。环孢素Ａ（ＣｓＡ）通过阻断ＣＤ３活化通路而产生免疫抑制效应，本文研究ＣｓＡ对ＣＤ２８活化通路的影响。研究发现以抗ＣＤ３单抗和抗ＣＤ２８单抗共刺激后，淋巴细胞增殖比以抗ＣＤ３单抗单独刺激时显著增强，且对ＣｓＡ不敏感，ＩＤ５０较单独刺激时高４～５倍。研究表明：ＣＤ２８通路能提供共刺激信号，使Ｔ细胞充分活化增殖，并且这一活化通路能对ＣｓＡ产生抵抗
T cells need more than two stimulation signals to fully activate. Cyclosporine A (CsA) blocks the CD3 activation pathway to produce immunosuppressive effects. This article studies the effect of CsA on the CD28 activation pathway. The results showed that when stimulated with anti-CD3 monoclonal antibody and anti-CD28 monoclonal antibody, the lymphocyte proliferation ratio was significantly increased when stimulated with anti-CD3 monoclonal antibody alone, and was not sensitive to CsA. ID50 was 4 to 5 times higher than that when stimulated alone. Studies have shown that: CD28 pathway can provide costimulatory signals, T cells to fully activate and proliferate, and this activation pathway can be resistant to CsA