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目的 :探讨系统性红斑狼疮 (SLE)与EB病毒感染的相关性。方法 :用标准ELISA和PCR法检测 117例未成年SLE患者和 15 3名未成年正常对照、以及 196例成人SLE患者和 392名成人正常对照的EBV感染情况。结果 :未成年组 116例患者 (116 /117)和 10 7名对照 (10 7/15 3)EBV -IgG阳性 (P <0 .0 0 1) ,成年组 195例患者 (195 /196 )和 370名对照 (370 /392 )EBV -IgG阳性 (P =0 .0 14 ) ;随机抽取各 32例 ,患者和对照EBV -DNA阳性为 32、2 3例 (P <0 .0 2 )。结论 :EB病毒感染与SLE相关 ,EB病毒感染可能是SLE的其中一个病因。
Objective: To investigate the relationship between systemic lupus erythematosus (SLE) and Epstein-Barr virus (EBV) infection. Methods: The prevalence of Epstein-Barr virus (EBV) infection in 117 cases of juvenile SLE and 15 3 cases of non-juvenile normal control and 196 cases of adult SLE and 392 cases of normal controls were detected by standard ELISA and PCR. Results: In the juvenile group, 116 patients (116/117) and 107 controls (10 7/15 3) were positive for EBV-IgG (P <0.01), 195 patients (195/196) in the adult group and 370 (39/392) were EBV-IgG positive (P = 0.014). 32 cases were randomly selected. The positive rates of EBV-DNA in patients and controls were 32,23 (P <0. Conclusion: Epstein-Barr virus infection is associated with SLE. Epstein-Barr virus (EBV) infection may be one of the causes of SLE.