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目的：研究基质金属蛋白酶－2（MMP－2）和组织基质金属蛋白酶抑制剂－2（TIMP－2）在人肺癌组织中的表达及其与淋巴结转移和预后的关系。方法：通过免疫组织化学的方法检测42例肺癌组织中MMP－2和TIMP－2表达的情况。结果：MMP－2和TIMP－2在肺癌中表达的阳性率分别为62％和31％；MMP－2的表达与淋巴结转移呈正相关，与术后生存期的长短呈负相关，而TIMP－2的表达则相反。结论：MMP－2和TIMP－2的表达与肺癌淋巴结转移与预后密切相关，可作为判断肺癌转移和预后的指标。
Objective: To investigate the expression of matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of matrix metalloproteinase-2 (TIMP-2) in human lung cancer and its relationship with lymph node metastasis and prognosis. Methods: The expression of MMP-2 and TIMP-2 in 42 lung cancer tissues was detected by immunohistochemistry. Results: The positive rates of MMP-2 and TIMP-2 expression in lung cancer were 62% and 31%, respectively; the expression of MMP-2 was positively correlated with lymph node metastasis, and negatively correlated with the length of survival time, and TIMP-2. The expression is the opposite. Conclusion: The expression of MMP-2 and TIMP-2 is closely related to lymph node metastasis and prognosis of lung cancer, and it can be used as an index to judge the metastasis and prognosis of lung cancer.