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目的:评价硝苯地平缓释片对稳定性心绞痛的长期疗效并与依那普利进行对比。方法:选择77例稳定性心绞痛患者,随机分为治疗组39例及对照组38例,两组均给予肠溶阿司匹林、β-受体组滞剂及他汀类长期口服,在此基础上,治疗组给予硝苯地平缓释片长期口服,对照组给予依那普利长期口服。随访3 a,观察两组3 a内临床事件发生率、3 a后心绞痛CCS分级变化情况及左心室EF值变化情况。结果:两组在3 a内临床事件发生率、3 a后心绞痛CCS分级变化情况及左心室EF值变化情况等方面无统计学差异(P>0.05),两组治疗后心绞痛CCS分级改善均较治疗前有统计学差异(P<0.05)。结论:硝苯地平缓释片长期治疗稳定性心绞痛与依那普利相比,疗效相似,两药均安全有效,可改善该病预后。
OBJECTIVE: To evaluate the long-term efficacy of nifedipine sustained-release tablets in patients with stable angina and to compare with enalapril. Methods: Totally 77 patients with stable angina were randomly divided into treatment group (39 cases) and control group (38 cases). Both groups were given enteric-coated aspirin, β-receptor blockers and statins for long-term oral administration. On this basis, Group given long-term oral administration of nifedipine sustained-release tablets, the control group was given enalapril long-term oral. After 3 years of follow-up, the incidence of clinical events within 3 years and the changes of CCS grading of angina pectoris and EF of left ventricle after 3 years were observed. Results: There was no significant difference in the incidence of clinical events within 3 years, CCS grading of angina pectoris after 3 years, changes of left ventricular EF value between the two groups (P> 0.05) Before treatment there was a significant difference (P <0.05). Conclusion: Nifedipine sustained-release tablets long-term treatment of stable angina compared with enalapril, the curative effect is similar, both drugs are safe and effective, can improve the prognosis of the disease.