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[目的 ] 增强对广州管圆线虫引起罕见的人类“嗜酸细胞增多性脑脊膜神经根炎”的认识。 [方法 ] 介绍1997年 10月爆发流行于浙江省温州市的广州管圆线虫病的病因探索过程 ,内容涉及疾病的爆发、联合研究组的建立、病因线索与传播途径的发现、疾病的控制、疫源学研究、血清免疫学诊断新方法的建立、临床特征的确定以及疫源地的新旁证等。 [结果 ] 论证了这起疾病的爆发是由广州管圆线虫引起的中枢神经系统幼虫移行症 ,总结了该病的临床学、流行病学、免疫诊断学之经验。 [结论 ] 本研究案例提供了该病的诊断与治疗手段以及控制与预防对策。
[Objective] To enhance the understanding of the rare human “eosinophilic meningeal root inflammation” caused by A. cantonensis in Guangzhou. [Method] The etiological exploration process of angiostrongylus elegans in Wenzhou City, Zhejiang Province, which broke out in October 1997, is introduced. The contents include the outbreak of disease, the establishment of joint research group, the discovery of etiological cues and transmission routes, the control of diseases, Epidemiological studies, the establishment of a new method for the diagnosis of serum immunology, the determination of clinical features and the new circumstantial evidence of foci. [Results] The outbreak of this disease was demonstrated to be the central nervous system larvae disease caused by the angiostrongylus cantonensis. The clinical, epidemiological and immunological diagnosis of the disease were summarized. [Conclusion] This study provides the diagnosis and treatment of the disease as well as the control and prevention measures.