论文部分内容阅读
复制林可霉素致豚鼠胆囊胆色素结石的模型（Ｂ组）；用维生素Ｅ（ＶＥ）抗氧化预防结石形成（Ｃ组）。在结石形成的早期，测定其胆囊胆汁中的丙二醛（ＭＤＡ）、粘蛋白（ＭＰ）、β－葡萄糖醛酸酶（β－Ｇ）和总胆红素（ＴＢ）的含量。结果表明：Ｂ、Ｃ两组胆囊胆汁中ＭＤＡ、ＭＰ、β－Ｇ和ＴＢ的含量比正常对照组（Ａ组）均显著增高。Ｂ、Ｃ两组间各成分无差异。Ｂ、Ｃ组ＭＤＡ含量的对数与ＭＰ或β－Ｇ含量的对数分别呈显著正相关。说明炎症等病理过程产生的自由基通过对胆道粘膜上皮的损伤，扰乱其功能，在林可霉素致豚鼠胆色素结石的过程中起一定的作用。
Copy of lincomycin-induced guinea pig gallbladder pigment stones model (B group); with vitamin E (VE) anti-oxidation of stone formation (C group). The content of malondialdehyde (MDA), mucin (MP), β-glucuronidase (β-G) and total bilirubin (TB) in gallbladder bile were measured in the early stage of stone formation. The results showed that the contents of MDA, MP, β-G and TB in group B and C were significantly higher than those in normal control group (group A). B, C no difference between the two components. The logarithm of MDA content in groups B and C was positively correlated with the logarithm of MP or β-G content respectively. Explain inflammation and other pathological processes free radicals through the epithelium of the bile duct injury, disrupt the function of lincomycin-induced guinea pig gallstones play a role in the process.