γδT细胞的生物学意义

• 作 者: 何维 巴德年
• 机 构: 中国医学科学院基础医学研究所,中国协和医科大学基础医学院微生物学及免疫学教研室 北京100005
• 出 处: 上海免疫学杂志
• 发表日期: 1997年01期
• 关键词: 免疫应答 抗原受体 细胞毒活性 淋巴细胞总数 细胞研究 α链 正常人外周血 外周淋巴细胞 β链 ceptor

T淋巴细胞表面可分别表达两种与CD3分子相关联的T细胞抗原受体(T cell re-ceptor,TCR):由α链和β链(TCRαβ)或γ链和δ链构成的异质二聚体.人们一直对αβT细胞的结构和功能研究予以很大程度上的关注,而对于γδT细胞研究投入要少些.主要原因可能是人们认为TCRγδ细胞是一个外周淋巴细胞库中的数量较小的亚群,不大可能在免疫应答中起主要作用.γδT细胞约占正常人外周血淋巴细胞总数的3%～10%,在其表面表达CD3分子,但绝大多数不表达CD4及CD8分子.然而在长期进

Two T cell re-ceptors (TCRs), which are associated with CD3 molecules, can be expressed on the surface of T lymphocytes, respectively. Heterobiotin B2s consisting of α and β chains (TCRαβ) or γ and δ chains Many studies have focused on the structure and function of αβ T cells and less on γδ T cell research.The main reason may be that the number of TCRγδ cells in a pool of peripheral lymphocytes is thought to be small Of subpopulations are unlikely to play a major role in the immune response.γδT cells account for about 3% -10% of the total number of normal peripheral blood lymphocytes, and express CD3 molecules on their surface, but most of them do not express CD4 and CD8 molecules However, in the long term