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目的总结新型隐球菌脑膜炎的临床特点。方法回顾性分析24例新型隐球菌脑膜炎患者的流行病学、临床表现、实验室检查及影像学资料。结果 24例患者中,男18例,女6例;12例为单纯脑膜炎,12例为脑膜脑炎。头痛23例,发热22例;脑膜刺激征阳性15例,肌力下降7例,听力下降2例。颅内压升高19例。14例治愈或明显好转,7例无明显改善,3例死亡。结论新型隐球菌脑膜炎临床表现多种多样,容易误诊。早期诊断和及时治疗是改善预后的关键。
Objective To summarize the clinical features of cryptococcal meningitis. Methods Retrospective analysis of 24 cases of Cryptococcus neoformans meningitis in patients with epidemiology, clinical manifestations, laboratory tests and imaging data. Results Of the 24 patients, 18 were male and 6 were female, 12 were meningitis and 12 were meningoencephalitis. 23 cases of headache, fever in 22 cases; 15 cases of positive meningeal irritation, decreased muscle strength in 7 cases, 2 cases of hearing loss. Intracranial pressure increased in 19 cases. 14 cases were cured or significantly improved, 7 cases no significant improvement, 3 patients died. Conclusion Cryptococcus neoformans meningitis clinical manifestations varied, easily misdiagnosed. Early diagnosis and timely treatment is the key to improving prognosis.