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本文运用物理化学相分析方法,系统地研究了盐酸硫胺两种结品变体的属性、生成条件、稳定性和转换机制。指出两种结晶变体分别是盐酸硫胺的一水和半水加成物。前者的溶解度大于后者。重结晶时,由于一水物生长速度较半水物大得多,从而改变了结晶方向,总是先析出一水加成物,陈化过程中再逐步溶解,重新以半水加成物形式析出。潮湿环境中,由于潮解或多分子层吸附在晶体表面上形成“液膜”,“液膜”中发生了类似陈化过程中的晶型转换,并伴随着结块现象。
In this paper, the properties, formation conditions, stability and conversion mechanism of two thiamine hydrochloride conjugates were studied systematically using phase-chemical analysis method. It is pointed out that the two crystal forms are the monohydrate and hemihydrate adducts of thiamine hydrochloride, respectively. The former is more soluble than the latter. During recrystallization, since monohydrate grows much faster than semi-hydrate and thus changes the direction of crystallization, a water adduct is always precipitated first, then gradually dissolves during the aging process, and then re-enters as a semi-water adduct Precipitation. In wet environments, a “liquid film” is formed on the surface of the crystal due to deliquescence or multi-molecular layer adsorption, and a similar conversion of the crystal form in the “liquid film” occurs with caking.