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乙型肝炎免疫球蛋白的主要适应症是对 HBV 的单一急性接触,必须尽快地使用含有高效价的抗—HBs。在地方性流行环境下,如血液透析室,可以考虑对易感职工用含抗—HBs 的免疫球蛋白预防。是用效价低的、还是用效价高的免疫球蛋白为好以及注射的剂量和次数,尚未定论。一般,抗—HBs 滴度较高的人对 HBV 有抵抗力,因此无需进行被动免疫预防。如果 HBsAg 阳性的血液已用敏感的检测方法摒除,以乙型肝炎免疫球蛋白进行被动免疫似乎不是输血后的适应症。因为在这种情况下大多数输血后肝炎不是由于 HBV 感染引起的。
The primary indication for hepatitis B immunoglobulin is a single acute exposure to HBV, which must be rapidly used with high titer anti-HBs. In endemic circumstances, such as hemodialysis, consider using anti-HBs-containing immunoglobulins for susceptible workers. Is the use of low titer, or high titer of immunoglobulin as well as the amount and frequency of injection has not yet been conclusive. In general, people with higher anti-HBs titers are resistant to HBV and therefore do not need passive immunization. If HBsAg-positive blood is excluded by a sensitive test, passive immunization with hepatitis B immunoglobulin appears to be not a post-transfusion indication. Because in this case most of the post-transfusion hepatitis is not caused by HBV infection.