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四环素是临床上应用很广的广谱抗菌素。一般认为四环素的毒性很小,是一种相当安全的抗菌素。常见的副作用有:恶心,呕吐,腹泻,药物热,皮疹;局部应用易发生皮炎,也易发生皮肤日光过敏症,并有诱发红斑性狼疮的报道;血液系统方面,报道有粒细胞减少症及全血细胞减少症,溶血性贫血;长期治疗,能产生肝脏形态上和功能上改变,负氮平衡。有人观察到四环素有使婴儿颅内压升高现象。近年对四环素的毒性,又有了进一步的认识和发现,首先注意到四环素能沉着于骨骼中及乳齿中。四环素沉着于牙质中使牙变黄色,妨碍牙齿的发育和釉质的形成。国外有人对50个口服四环素儿童(1岁)进行了调查,发现:(1)牙齿色素沉着的发生率极高;(2)牙齿釉质发育不全,釉质凹陷及牙尖的畸形;(3)观察到有色素沉着的牙齿,容易成龋齿,有些为猖獗性龋齿。1957年有人报告在骨和肿瘤中,有四环素萤光性
Tetracycline is a widely used broad-spectrum antibiotics in clinical practice. Tetracycline is generally considered very toxic and is a fairly safe antibiotic. Common side effects are: nausea, vomiting, diarrhea, drug fever, rash; topical dermatitis prone to occur, but also prone to skin sun allergies, and have been reported lupus erythematosus; the blood system, reports of neutropenia and Pancytopenia, hemolytic anemia; long-term treatment, can produce liver morphological and functional changes, negative nitrogen balance. It has been observed tetracycline has increased the phenomenon of infants with intracranial pressure. In recent years, the toxicity of tetracycline, and further understanding and discovery, first noted that tetracycline can be settled in bones and milk teeth. Tetracycline is deposited in the dentin to yellow the teeth, preventing tooth development and enamel formation. Some 50 oral tetracycline children (1 year old) were investigated and found that: (1) the incidence of extremely high levels of pigmentation; (2) dental enamel hypoplasia, enamel depression and cusp deformity; (3) observed To pigmented teeth, easy to become dental caries, some rampant caries. It was reported in 1957 in bone and tumors, tetracycline fluorescent