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为研究幼年类风湿病（ＪＲＤ）患儿血清可溶性白细胞介素２受体（ＳＩＬ—２Ｒ）水平的变化，我们采用双抗体夹心间接ＥＬＩＳＡ法检测了２０例ＪＲＤ患儿和正常儿童血清ＳＩＬ—２Ｒ。结果显示：活动期血清ＳＩＬ—２Ｒ水平较缓解期和正常对照明显增高（Ｐ＜０．０１），并和红细胞沉降率（ＥＳＲ）呈正相关，４例复发患儿血清ＳＩＬ—２Ｒ水平再度升高。提示ＪＲＤ活动期血清ＳＩＬ—２Ｒ水平的变化可反映它的病情及判断其是否活动的标志。
To investigate the changes of serum soluble interleukin 2 receptor (sIL-2R) in children with rheumatoid arthritis (JRD), we detected the serum levels of SIL-2R in 20 children with JRD and normal controls by indirect ELISA . The results showed that the serum level of SIL-2R in active stage was significantly higher than that in remission stage and normal control group (P <0.01), and positively correlated with erythrocyte sedimentation rate (ESR). Serum SIL-2R level in 4 relapsed children increased again . Tip JRD activity changes in serum SIL-2R levels reflect its condition and to determine whether it is a sign of activity.